Cleveland suffered its fifth setback in a row and lost all three games on a recent road trip, including Tuesday's 117-97 loss to lowly Philadelphia.
J.J. Hickson scored 18 points, Daniel Gibson added 16 points off the bench and Mo Williams chipped in 15 points for the Cavs, who were outrebounded by a 44-29 margin and lost despite making 50 percent of their shots.
"I'm very disappointed with this whole road trip," said Cleveland head coach Byron Scott. "I don't know where the sense or urgency is right now, especially on the defensive end. We have to be much, much better."
The Cavaliers have lost two in a row at home and are 4-6 at the Q.
Meanwhile, Chicago has won two in a row since a two-game slide and recorded a 99-90 victory over Oklahoma City on Monday.
Newcomer Carlos Boozer posted a season-best 29 points to go along with 12 rebounds and Luol Deng registered 19 points and eight rebounds for the Bulls, who got just 11 points from All-Star guard Derrick Rose.
"I just try to do whatever I can," Boozer said. "My job is to be aggressive offensively and I will be. My job is to play good defense and rebound the ball, so that's what I'm focused on."
Kyle Korver had 13 points off the bench in a winning cause.
The Bulls are 4-6 away from the Windy City this season.
Chicago and Cleveland split four meetings a season ago. It has dropped 10 of 13 and 15 of the last 20 trips to the Forest City