The loss was Cleveland's seventh in its last eight games. They committed 27 turnovers on the night. They fell to 5-19 on the season.
Kyrie Irving played in his third-straight game, scoring 26 points in the loss.
The Bulls (12-9) won their fourth game in their last five to keep pace with the Bucks at the top of the division. Chicago will host Brooklyn at 8 p.m. ET Saturday.
Indiana won its second-consecutive game, a 95-85 decision over Philadelphia, to move to 12-11 on the season. They are in sole possession of third place in the Central, trailing the Bucks and Bulls by one game.
Detroit (7-18) is seven games out of first place, having lost 107-105 in double-overtime to Brooklyn Friday. It was their fifth loss in their last six games.