Masterson will square off against White Sox starter John Danks Tuesday in the third game of a four-game series between the AL Central rivals.
Masterson logged his first win of the season on May 3 against the White Sox. It wasn't all that pretty -- Masterson gave up eight hits and three walks in 6.1 innings -- but his six strikeouts, coupled with the offense's seven runs, proved to be enough.
On the season Masterson is 1-2 with a 5.20 ERA.
Danks, who also started on May 3, is 2-4 with a 6.51 ERA. In that May 3 contest, Danks gave up six earned runs in seven innings.
Fueled in part by their recent run against the Sox, Cleveland, 17-11, has opened up a three-game lead in the Central. Detroit is second at 14-14 and Chicago third at 13-17.
First pitch Tuesday is scheduled for 7:05 ET.