Columbus, OH (Sports Network) – Terrelle Pryor threw three first-half touchdowns, and second-ranked Ohio State rolled to a 38-10 victory over Indiana.

Pryor had a career-high 334 yards on 24-of-30 efficiency in just over three quarters of play. Daniel Herron ran for a pair of touchdowns for the Buckeyes (6-0, 2-0 Big Ten), who have won 12 straight games dating back to last season.

Head coach Jim Tressel earned his 100th career win at Ohio State.

Ben Chappell completed 16-of-26 passes for 106 yards with two interceptions for the Hoosiers (3-2, 0-2), who have dropped consecutive games after starting the season with wins over Towson, Western Kentucky and Akron. Indiana lost a shootout with nationally-ranked Michigan last week, as Heisman hopeful Denard Robinson ran for the winning touchdown in the waning moments of the fourth quarter.

Chappell set a school-record with 480 passing yards while also breaking the program’s marks for attempts (64) and completions (45) in the loss to the Wolverines.