The Cavs are 3-13 as the visitor this season and lost their fourth straight overall with Tuesday's 110-95 setback versus the Orlando Magic at Quicken Loans Arena. Antawn Jamison finished with 21 points and Daniel Gibson had 15 points and six boards for Cleveland, which has just one win in its last 15 contests overall and was outscored, 35-21, in the fourth quarter.
"Thirty-six good minutes of basketball. That's basically what we played. We didn't play very well in the fourth quarter," Cavs head coach Byron Scott said.
Mo Williams and Anderson Varejao both had 14 points in defeat.
Cleveland will also make a stop in Chicago on the quick trek.
Charlotte, meanwhile, began the Paul Silas era on a positive note with Monday's 105-100 triumph over the Detroit Pistons at home.
D.J. Augustin scored 27 points and Stephen Jackson added 23 for the Bobcats, who snapped a four-game slide and won for only the second time in its last eight overall.
The 67-year-old Silas took over for Larry Brown, who resigned from his post on Wednesday after the Bobcats got off to a 9-19 start this season. Silas returned to the NBA coaching ranks for the first time since he was fired by the Cleveland Cavaliers near the end of the 2004-05 season.
"It was great," Silas said about returning to coaching. "It brought back old memories; it just comes back to you. You just want to win. You tell the players what they're doing, and I've got great assistant coaches that are helping me. It's going to take some time but I liked the effort tonight. If we continue to play with this kind of effort then it's unbelievable what we can do."
In injury news for the Bobcats, Tyrus Thomas, who had 14 points off the bench in the win, is probable for tonight with a sore right wrist. Forward Gerald Wallace (ankle) is listed as questionable and has missed five straight games.
The Bobcats will also host Golden State and Miami on their current five-game residency is 7-7 at home this season. They won three of four matchups with Cleveland last year, but the Cavs are 16-6 in the previous 22 contests in this series.