The Cavaliers dropped to 1-1 on the season following a 115-86 beatdown at the hands of the Bulls on Friday night at Quicken Loans Arena.
Carlos Boozer and Richard Hamilton paced the Bulls with 19 points apiece, while Nate Robinson chipped in 16 points and 12 assists as Chicago never trailed. The Cavs got 15 points from Kyrie Irving and 12 points from both Anderson Varejao and Alonzo Gee.
The win left the Bulls alone atop the Central Division and the Cavs in a third-place tie with the Pacers, who handed the Bobcats a season-opening 90-89 victory after Charlotte had lost its final 23 games of the 2011-12 season.
The Bucks defeated the hosting Celtics, 99-88, to begin the season 1-0 behind a 21-point, 13-assist performance from Brandon Jennings.
The Pistons fell to 0-2 and sit in last place in the Central following a 92-89 loss to the Suns.
In other action around the league, the Clippers dropped the new-look Lakers to 0-3 with a 105-95 win and the Knicks romped over the defending champion Heat, 104-84. James Harden had his second sterling performance in leading the Rockets over the Hawks, 109-102, and the Magic scored a solid home win over the Nuggets, 102-89.
Head here to view the full scoreboard of Friday's NBA contests.