Cleveland players who are out include linebacker Titus Brown, defensive back Eric Hagg and offensive tackle Tony Pashos.
Probables for the Browns include wide receivers Mohamed Massaquoi and Carlton Mitchell and defensive backs Dmitri Patterson, T.J. Ward and Usama Young.
The Colts are obviously without quarterback Peyton Manning, but will also be missing linebackers Gary Brackett and Ernie Sims.
Questionable for Indianapolis are defensive ends Tyler Brayton and Robert Mathis, defensive tackle Eric Foster, linebacker Kavell Conner, tight end Brody Eldridge, and wide receivers Blair White and Anthony Gonzalez.
Probable for the Colts are defensive end Dwight Freeney and wide receiver Reggie Wayne.