Both Mouton and Royal did not practice on Friday after being limited on Thursday.
Royal has 13 receptions for 98 yards and one touchdown in six games for the Chargers this season.
Jared Gaither, Nick Hardwick, Vaughn Martin and Shareece Wright all participated in practice on Friday and are listed as questionable for Sunday.
The complete San Diego injury list is below:
OT Jared Gaither (Groin) - Probable
C Nick Hardwick (Abdomen) - Probable
DE-DT Vaughn Martin (Neck) - Probable
LB Jonas Mouton (Hip) - Questionable
WR-KR Eddie Royal (Hamstring) - Questionable
CB Shareece Wright (Foot) - Probable