Shin-Soo Choo opened the scoring with a solo home run, just his sixth of the season, in the first inning. Joey Votto tied it at 1 with a homer of his own in the bottom of the first.
Scott Rolen and Ryan Hanigan both had RBI singles in the top of the second, but the Indians took a one-run lead into the third. Lonnie Chisenhall homered to deep right in the bottom of the second.
Cincinnati scored two in the third after Ryan Ludwick doubled in Brandon Phillips and Scott Rolen singled in Jay Bruce.
Cleveland took the lead back in the fourth after a homer from Casey Kotchman and an RBI-double from Choo.
Phillips scored Votto on a double in the second and, on the same at-bat, a fielding error from Johnny Damon allowed Phillips to score.
Reds starting pitcher Mat Latos was replaced by Sam LeCure after giving up seven runs in four innings. Joe Smith replaced Indians starter Derek Lowe after Lowe gave up seven in five innings.