In the fourth inning, Johnny Damon hit a two-run home run to open the scoring. Later in that same inning, Asdrubal Cabrera followed it up with a three-run shot.
Cabrera's blast is his second home run in as many days. He hit a walk-off, two-run homer in the bottom of the tenth Tuesday night to give the Indians a win.
Reds pitcher Bronson Arroyo was replaced by Alfredo Simon after that fourth inning. Arroyo gave up five hits, walked two and struck out two.
Indians pitcher Justin Masterson has given up only two hits in seven innings of work, with four strikeouts.