Heading into Saturday's game, having been shut out 4-0 by Tigers ace Justin Verlander and Detroit's bullpen Friday, the Indians fell to 10-36 since that game.
They still have a 9-7 record against the Tigers, and they'll look to take the season series with a win Saturday at Progressive Field in Cleveland.
Justin Masterson (11-13, 4.96 ERA) is on the mound for the Indians, bringing with him two wins this season against the Tigers. The last one came on Sept. 4, when he pitched six innings, allowing just two earned runs.
Masterson was hit hard in his last start, though, allowing six earned runs in six and two-thirds innings, taking his 13th loss of the season.
The Tigers counter with Anibal Sanchez, who's put up a 1-1 record against Cleveland this year with a 1.42 ERA.
First pitch is scheduled for 4:05 p.m. ET.