Minnesota jumped out to a 4-0 lead after three innings, chasing Cleveland starter Jeanmar Gomez from the game. But the Indians scored two runs in the fourth and two more in the fifth to tie it. Russ Canzler had a 2-run home run in the fourth, then Shin-Soo Choo and Canzler hit RBI-singles in the fifth.
The Indians took the lead with three runs in the seventh on RBI singles by Michael Brantley and Casey Kotchman. The third run came when Cord Phelps drew a bases-loaded walk.
The Twins scored runs in the eighth and the ninth to cut the lead to one, but Cleveland closer Chris Perez was able to get the final outs to pick up the save.
David Huff (1-0, 0.00 ERA) picked up the win, pitching 3.1 innings of scoreless relief.